Mouse Monoclonal Anti-Human CD8 IgG |
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AB-14810 | Alpha Diagnostics | 100 ug | EUR 416.4 |
Human IgG antibody Laboratories manufactures the rabbit anti cd8 antibody abcam reagents distributed by Genprice. The Rabbit Anti Cd8 Antibody Abcam reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To purchase these products, for the MSDS, Data Sheet, protocol, storage conditions/temperature or for the concentration, please contact rabbit Antibody. Other Rabbit products are available in stock. Specificity: Rabbit Category: Anti Group: Cd8 Antibody
Mouse Monoclonal Anti-Human CD8-FITC IgG |
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Alpha Diagnostics | 100 ug | EUR 416.4 |
Mouse Monoclonal Anti-Human CD8-biotinylated IgG |
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Alpha Diagnostics | 100 ug | EUR 416.4 |
Anti-CD8 Antibody |
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HUABIO | 100ul | EUR 189 |
Description: CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell-antigen interactions. Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the MHC class I protein. There are two isoforms of the protein, alpha and beta, each encoded by a different gene. In humans, both genes are located on chromosome 2 in position 2p12. The CD8 co-receptor is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells, cortical thymocytes, and dendritic cells. The CD8 molecule is a marker for cytotoxic T cell population. It is expressed in T cell lymphoblastic lymphoma and hypo-pigmented mycosis fungoides. The extracellular IgV-like domain of CD8-α interacts with the α3 portion of the Class I MHC molecule. This affinity keeps the T cell receptor of the cytotoxic T cell and the target cell bound closely together during antigen-specific activation. Cytotoxic T cells with CD8 surface protein are called CD8+ T cells. The main recognition site is a flexible loop at the α3 domain of an MHC molecule. This was discovered by doing mutational analyses. The flexible α3 domain is located between residues 223 and 229 in the genome. In addition to aiding with cytotoxic T cell antigen interactions the CD8 co-receptor also plays a role in T cell signaling. The cytoplasmic tails of the CD8 co-receptor interact with Lck (lymphocyte-specific protein tyrosine kinase). Once the T cell receptor binds its specific antigen Lck phosphorylates the cytoplasmic CD3 and ζ-chains of the TCR complex which initiates a cascade of phosphorylation eventually leading to activation of transcription factors like NFAT, NF-κB, and AP-1 which affect the expression of certain genes. |
Anti-CD8 Antibody |
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EnoGene | 100ug/100ul | EUR 225 |
Description: Available in various conjugation types. |
Anti-CD8 Antibody |
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ABM | 100 µg | EUR 450 |
Anti-CD8 antibody |
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St John's Laboratory | 1 mL | EUR 294 |
Anti-CD8 antibody |
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St John's Laboratory | 100 µg | EUR 487.2 |
Anti-CD8 alpha Antibody, Rabbit Polyclonal |
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MBS8111477-5x01mL | MyBiosource | 5x0.1mL | EUR 1200 |
Anti-CD8 alpha Antibody, Rabbit Polyclonal |
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MBS8111478-002mL | MyBiosource | 0.02mL | EUR 175 |
Anti-CD8 alpha Antibody, Rabbit Polyclonal |
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MBS8111478-01mL | MyBiosource | 0.1mL | EUR 320 |
Anti-CD8 alpha Antibody, Rabbit Polyclonal |
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MBS8111478-5x01mL | MyBiosource | 5x0.1mL | EUR 1300 |
Anti-CD8 alpha Antibody, Rabbit Polyclonal |
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MBS8112453-01mL | MyBiosource | 0.1mL | EUR 300 |
Anti-CD8 alpha Antibody, Rabbit Polyclonal |
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MBS8112453-5x01mL | MyBiosource | 5x0.1mL | EUR 1200 |
Anti-CD8 alpha Antibody, Rabbit Polyclonal |
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MBS8124183-01mL | MyBiosource | 0.1mL | EUR 300 |
Anti-CD8 alpha Antibody, Rabbit Polyclonal |
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MBS8124183-5x01mL | MyBiosource | 5x0.1mL | EUR 1200 |
Anti-CD8 alpha Rabbit Monoclonal Antibody |
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MBS179815-01mL | MyBiosource | 0.1mL | EUR 450 |
Anti-CD8 alpha Rabbit Monoclonal Antibody |
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MBS179815-5x01mL | MyBiosource | 5x0.1mL | EUR 1870 |
Anti-CD8 alpha Rabbit Monoclonal Antibody |
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1280-100uL | Gene Universal | 100 μL | EUR 329 |
Anti-CD8 alpha Rabbit Monoclonal Antibody |
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1280-20uL | Gene Universal | 20 μL | EUR 129 |
ABCA4 Rabbit anti-Human Polyclonal Antibody |
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MBS2403219-005mg | MyBiosource | 0.05mg | EUR 615 |
ABCA4 Rabbit anti-Human Polyclonal Antibody |
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MBS2403219-5x005mg | MyBiosource | 5x0.05mg | EUR 2605 |
ABCA7 Rabbit anti-Human Polyclonal Antibody |
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MBS2403220-005mg | MyBiosource | 0.05mg | EUR 615 |
ABCA7 Rabbit anti-Human Polyclonal Antibody |
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MBS2403220-5x005mg | MyBiosource | 5x0.05mg | EUR 2605 |
MOUSE ANTI RABBIT CD8 |
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MBS224404-01mg | MyBiosource | 0.1mg | EUR 390 |